The Water Distribution Automatic Control Management System in the Water Production Room is a pharmaceutical water distribution and transportation management system and equipment specially designed and manufactured by the Engineering Technology Department of Nanjing Novo. The control system uses Siemens automatic components as the main control elements, mainly consisting of Siemens S7-200PLC, M440 frequency converter and MCGS touch screen, supplemented by some on-site sensors such as flow rate, conductivity and temperature to control and record the quality of water. This system can meet the requirements of CGMP for pharmaceutical water distribution and transportation systems. The power and fluid part is composed of sanitary centrifugal pumps, pneumatic diaphragm valves, pneumatic components and clean stainless-steel fluid pipe fittings. 

　　The purified water distribution control system mainly includes the control of flow rate, conductivity, low-level alarm handling of the storage tank, pneumatic valves, etc. The electrical control consists of an electrical control cabinet, frequency converter, on-site sensors, various actuating components, PLC and touch screen. Pasteurization is adopted for purified water sterilization: when the water in the tank is heated to 80°C through an on-line heat exchanger, the sterilization timing starts. The sterilization time can be set manually, and automatic temperature control is achieved during the heating process. The injection water distribution control system mainly includes the control of flow rate, conductivity, temperature, low-level alarm handling of the storage tank, pneumatic valves, etc. 

　　For injection water sterilization, pure steam or superheated water sterilization is adopted(superheated water sterilization: when the water in the tank is heated to 122°C through an on-line heat exchanger, the sterilization timing starts. The sterilization time can be set manually, and automatic temperature control should be achieved during the heating process). When the system enters the sterilization (SIP)state, the sterilization time can only be recorded after the temperature at the coldest point reaches 122°C. If the temperature during the sterilization process is lower than 122°C within the set time, the sterilization timing needs to be restarted. 

　　Data recording: Tank liquid level / Monitoring point temperature / Return water conductivity / Return water flow rate, original operating frequency, etc. The signals are printed and recorded through the configured chart recorder. 

Due to the needs of process producton, the temperature of some njection water usage poits needs to be reduced, such as water for batching, cleaning water, and water fo other producion processes When hot water usagepoints and low-temperature waterusagepointscoesit inth samecrculaton oop and the numberoflow-temperture waterusagepoit ssmall usng a inglepoint heatechangesystem is agood opton. The commonlyused design conceptsforsingle-point cooling manmy ncldetyo ypes th "single-point coolingsystemafter the water usage point" and the "Subloop cooling system". 

Thesingle-point cooling sytem afer the waterusagepointachieves thesinglepointcoing functon yinstalingatet exchanger threar endofthewate usae pont thstmuses a double-plate tutbe heat echanger forinstant cooling To prevent microbialcontamination, piresteam canbeused tointemitntly rerlrethe hetechaner ndthe ownstreampipoeline The main advantages of this design method arethtth risko contaminatontothemain phamceuticl htersystemislow, and thesysem interfoce is eryclean is manmlyusedtoreduce the temperature ofijection water at the water usage poits ofeuipment sich as aching tnes an botle washing mazcins. however, sinethe et echanger ispaord i erthe valve of the waterusagepoint the heat uxchanger generll needs to e intalled inacean rom, an theveare igh requirement fortheceaniress an instlatonspace f the clean room. 

The Subloop cooling system must install an orifice plate or a diaphragm valve on the main pipe network to create a certain back-pressure to ensure sufficient turbulence in the branch pipe networksystem. For the injection water cold-water usage points designed with theSubloop cooling system, close attention must be paid to the impact of thecooling water side on the service life of the heat exchanger. When the heatexchanger at the cold-water usage point stops cooling, part of the coolingwater remains at the shell-side of the heat exchanger. If the cooling water ispurged and drained from the heat exchanger, a small amount of residualcooling water in the shell-side combined with air may cause corrosion onthe outer side of the heat exchanger, thus affecting the service life andsafety of the heat exchanger. Therefore, the US FDA "High-Purity WaterInspection Guide" recommends that when the heat exchanger is not inoperation, the cooling water in the shell does not need to be discharged.